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Impairment of BRCA1-related DNA Double Strand Break Repair Leads to Ovarian Aging in Mice and Humans
The underlying mechanism behind age-induced wastage of the human ovarian follicle reserve is unknown. In this study, we identify impaired ATM (ataxia-telengiectasia mutated)-mediated DNA double strand break (DSB) repair as a cause of aging in mouse and human oocytes. We show that DSBs accumulate in...
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| Publicado no: | Sci Transl Med |
|---|---|
| Main Authors: | , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5130338/ https://ncbi.nlm.nih.gov/pubmed/23408054 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.3004925 |
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