Impairment of BRCA1-related DNA Double Strand Break Repair Leads to Ovarian Aging in Mice and Humans

The underlying mechanism behind age-induced wastage of the human ovarian follicle reserve is unknown. In this study, we identify impaired ATM (ataxia-telengiectasia mutated)-mediated DNA double strand break (DSB) repair as a cause of aging in mouse and human oocytes. We show that DSBs accumulate in...

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Bibliografische gegevens
Gepubliceerd in:Sci Transl Med
Hoofdauteurs: Titus, Shiny, Li, Fang, Stobezki, Robert, Akula, Komala, Unsal, Evrim, Jeong, Kyungah, Dickler, Maura, Robson, Mark, Moy, Fred, Goswami, Sumanta, Oktay, Kutluk
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2013
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5130338/
https://ncbi.nlm.nih.gov/pubmed/23408054
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.3004925
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