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Declining BRCA-Mediated DNA Repair in Sperm Aging and its Prevention by Sphingosine-1-Phosphate

ABSTRACT: Recent data suggest that paternal age can have major impact on reproductive outcomes, and with increased age, there is increased likelihood of chromosomal abnormalities in the sperm. Here, we studied DNA damage and repair as a function of male aging and assessed whether sphingosine-1-phosp...

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Detalhes bibliográficos
Publicado no:Reprod Sci
Main Authors: Stobezki, Robert, Titus, Shiny, Halicka, Dorota, Darzynkiewicz, Zbigniew, Oktay, Kutluk
Formato: Artigo
Idioma:Inglês
Publicado em: Springer International Publishing 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7065969/
https://ncbi.nlm.nih.gov/pubmed/31916095
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s43032-019-00098-1
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