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Declining BRCA-Mediated DNA Repair in Sperm Aging and its Prevention by Sphingosine-1-Phosphate

ABSTRACT: Recent data suggest that paternal age can have major impact on reproductive outcomes, and with increased age, there is increased likelihood of chromosomal abnormalities in the sperm. Here, we studied DNA damage and repair as a function of male aging and assessed whether sphingosine-1-phosp...

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Podrobná bibliografie
Vydáno v:Reprod Sci
Hlavní autoři: Stobezki, Robert, Titus, Shiny, Halicka, Dorota, Darzynkiewicz, Zbigniew, Oktay, Kutluk
Médium: Artigo
Jazyk:Inglês
Vydáno: Springer International Publishing 2020
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7065969/
https://ncbi.nlm.nih.gov/pubmed/31916095
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s43032-019-00098-1
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