Histone demethylase KDM6A directly senses oxygen to control chromatin and cell fate

Oxygen sensing is central to metazoan biology and has implications for human disease. Mammalian cells express multiple oxygen-dependent enzymes called 2-oxoglutarate (OG)-dependent dioxygenases (2-OGDDs), but they vary in their oxygen affinities and hence their ability to sense oxygen. The 2-OGDD hi...

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Publicado no:Science
Main Authors: Chakraborty, Abhishek A., Laukka, Tuomas, Myllykoski, Matti, Ringel, Alison E., Booker, Matthew A., Tolstorukov, Michael Y., Jeff Meng, Yuzhong, Meier, Samuel R., Jennings, Rebecca B., Creech, Amanda L., Herbert, Zachary T., Spinelli, Jessica, McBrayer, Samuel K., Olenchock, Benjamin A., Jaffe, Jacob D., Haigis, Marcia C., Beroukhim, Rameen, Signoretti, Sabina, Koivunen, Peppi, Kaelin, William G.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7336390/
https://ncbi.nlm.nih.gov/pubmed/30872525
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aaw1026
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