The KDM5A/RBP2 histone demethylase represses NOTCH signaling to sustain neuroendocrine differentiation and promote small cell lung cancer tumorigenesis

More than 90% of small cell lung cancers (SCLCs) harbor loss-of-function mutations in the tumor suppressor gene RB1. The canonical function of the RB1 gene product, pRB, is to repress the E2F transcription factor family, but pRB also functions to regulate cellular differentiation in part through its...

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Detalhes bibliográficos
Publicado no:Genes Dev
Main Authors: Oser, Matthew G., Sabet, Amin H., Gao, Wenhua, Chakraborty, Abhishek A., Schinzel, Anna C., Jennings, Rebecca B., Fonseca, Raquel, Bonal, Dennis M., Booker, Matthew A., Flaifel, Abdallah, Novak, Jesse S., Christensen, Camilla L., Zhang, Hua, Herbert, Zachary T., Tolstorukov, Michael Y., Buss, Elizabeth J., Wong, Kwok-Kin, Bronson, Roderick T., Nguyen, Quang-De, Signoretti, Sabina, Kaelin, William G.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2019
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6942053/
https://ncbi.nlm.nih.gov/pubmed/31727771
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.328336.119
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