Histone demethylase KDM5A is an integral part of the core Notch–RBP-J repressor complex

Timely acquisition of cell fates and the elaborate control of growth in numerous organs depend on Notch signaling. Upon ligand binding, the core transcription factor RBP-J activates transcription of Notch target genes. In the absence of signaling, RBP-J switches off target gene expression, assuring...

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Dettagli Bibliografici
Autori principali: Liefke, Robert, Oswald, Franz, Alvarado, Cristobal, Ferres-Marco, Dolores, Mittler, Gerhard, Rodriguez, Patrick, Dominguez, Maria, Borggrefe, Tilman
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cold Spring Harbor Laboratory Press 2010
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2841336/
https://ncbi.nlm.nih.gov/pubmed/20231316
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.563210
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