RBP-Jκ/SHARP Recruits CtIP/CtBP Corepressors To Silence Notch Target Genes

Notch is a transmembrane receptor that determines cell fates and pattern formation in all animal species. After ligand binding, proteolytic cleavage steps occur and the intracellular part of Notch translocates to the nucleus, where it targets the DNA-binding protein RBP-Jκ/CBF1. In the absence of No...

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Detalhes bibliográficos
Main Authors: Oswald, Franz, Winkler, Michael, Cao, Ying, Astrahantseff, Kathy, Bourteele, Soizic, Knöchel, Walter, Borggrefe, Tilman
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2005
Assuntos:
Gene Expression
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1291242/
https://ncbi.nlm.nih.gov/pubmed/16287852
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.23.10379-10390.2005
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