Histone demethylase KDM6A directly senses oxygen to control chromatin and cell fate

Oxygen sensing is central to metazoan biology and has implications for human disease. Mammalian cells express multiple oxygen-dependent enzymes called 2-oxoglutarate (OG)-dependent dioxygenases (2-OGDDs), but they vary in their oxygen affinities and hence their ability to sense oxygen. The 2-OGDD hi...

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Udgivet i:Science
Main Authors: Chakraborty, Abhishek A., Laukka, Tuomas, Myllykoski, Matti, Ringel, Alison E., Booker, Matthew A., Tolstorukov, Michael Y., Jeff Meng, Yuzhong, Meier, Samuel R., Jennings, Rebecca B., Creech, Amanda L., Herbert, Zachary T., Spinelli, Jessica, McBrayer, Samuel K., Olenchock, Benjamin A., Jaffe, Jacob D., Haigis, Marcia C., Beroukhim, Rameen, Signoretti, Sabina, Koivunen, Peppi, Kaelin, William G.
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7336390/
https://ncbi.nlm.nih.gov/pubmed/30872525
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aaw1026
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