Fumarate and Succinate Regulate Expression of Hypoxia-inducible Genes via TET Enzymes

The TET enzymes are members of the 2-oxoglutarate-dependent dioxygenase family and comprise three isoenzymes in humans: TETs 1–3. These TETs convert 5-methylcytosine to 5-hydroxymethylcytosine (5-hmC) in DNA, and high 5-hmC levels are associated with active transcription. The importance of the balan...

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Bibliographische Detailangaben
Veröffentlicht in:J Biol Chem
Hauptverfasser: Laukka, Tuomas, Mariani, Christopher J., Ihantola, Tuukka, Cao, John Z., Hokkanen, Juho, Kaelin, William G., Godley, Lucy A., Koivunen, Peppi
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2016
Schlagworte:
Enzymology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4759199/
https://ncbi.nlm.nih.gov/pubmed/26703470
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.688762
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