Autochthonous tumors driven by Rb1 loss have an ongoing requirement for the RBP2 histone demethylase

Inactivation of the retinoblastoma gene (RB1) product, pRB, is common in many human cancers. Targeting downstream effectors of pRB that are central to tumorigenesis is a promising strategy to block the growth of tumors harboring loss-of-function RB1 mutations. One such effector is retinoblastoma-bin...

Descripción completa

Guardado en:
Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Autores principales: McBrayer, Samuel K., Olenchock, Benjamin A., DiNatale, Gabriel J., Shi, Diana D., Khanal, Januka, Jennings, Rebecca B., Novak, Jesse S., Oser, Matthew G., Robbins, Alissa K., Modiste, Rebecca, Bonal, Dennis, Moslehi, Javid, Bronson, Roderick T., Neuberg, Donna, Nguyen, Quang-De, Signoretti, Sabina, Losman, Julie-Aurore, Kaelin, William G.
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2018
Materias:
PNAS Plus
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5910822/
https://ncbi.nlm.nih.gov/pubmed/29610306
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1716029115
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares