TMOD-14. CREATION OF A GENETICALLY ENGINEERED MOUSE MODEL OF ANAPLASTIC ASTROCYTOMA DRIVEN BY THE IDH1-R132H ONCOGENE

Despite the high prevalence of IDH1-R132H mutations in lower grade gliomas, the ability to study this mutation in vivo has been hampered by a lack of faithful mouse models. Therefore, we used a CRISPR/Cas9- and AAV-based strategy to create a genetically engineered mouse model (GEMM) of astrocytoma d...

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Detalhes bibliográficos
Publicado no:Neuro Oncol
Main Authors: Shi, Diana, Wang, Adam, Gao, Wenhua, Khanal, Januka, Levitt, Michael, Jennings, Rebecca, Bonal, Dennis, Signoretti, Sabina, Nguyen, Quang-De, Cahill, Daniel, Abdullah, Kalil, Ligon, Keith, Kaelin, William, McBrayer, Samuel
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
Assuntos:
Tumor Models
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7651090/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa215.965
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