Somatic Mosaicism of IDH1 R132H Predisposes to Anaplastic Astrocytoma: A Case of Two Siblings

Anaplastic astrocytomas are aggressive glial cancers that present poor prognosis and high recurrence. Heterozygous IDH1 R132H mutations are common in adolescent and young adult anaplastic astrocytomas. In a majority of cases, the IDH1 R132H mutation is unique to the tumor, although rare cases of ana...

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Detalhes bibliográficos
Publicado no:Front Oncol
Main Authors: Lee, Sulgi, Kambhampati, Madhuri, Almira-Suarez, M. Isabel, Ho, Cheng-Ying, Panditharatna, Eshini, Berger, Seth I., Turner, Joyce, Van Mater, David, Kilburn, Lindsay, Packer, Roger J., Myseros, John S., Vilain, Eric, Nazarian, Javad, Bornhorst, Miriam
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Oncology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6971203/
https://ncbi.nlm.nih.gov/pubmed/32010615
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2019.01507
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