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Direct Extracellular NAMPT Involvement in Pulmonary Hypertension and Vascular Remodeling. Transcriptional Regulation by SOX and HIF-2α

We previously demonstrated involvement of NAMPT (nicotinamide phosphoribosyltransferase) in pulmonary arterial hypertension (PAH) and now examine NAMPT regulation and extracellular NAMPT’s (eNAMPT’s) role in PAH vascular remodeling. NAMPT transcription and protein expression in human lung endothelia...

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Detalhes bibliográficos
Publicado no:Am J Respir Cell Mol Biol
Main Authors: Sun, Xiaoguang, Sun, Belinda L., Babicheva, Aleksandra, Vanderpool, Rebecca, Oita, Radu C., Casanova, Nancy, Tang, Haiyang, Gupta, Akash, Lynn, Heather, Gupta, Geetanjali, Rischard, Franz, Sammani, Saad, Kempf, Carrie L., Moreno-Vinasco, Liliana, Ahmed, Mohamed, Camp, Sara M., Wang, Jian, Desai, Ankit A., Yuan, Jason X.-J., Garcia, Joe G. N.
Formato: Artigo
Idioma:Inglês
Publicado em: American Thoracic Society 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7328254/
https://ncbi.nlm.nih.gov/pubmed/32142369
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2019-0164OC
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