Direct Extracellular NAMPT Involvement in Pulmonary Hypertension and Vascular Remodeling. Transcriptional Regulation by SOX and HIF-2α

We previously demonstrated involvement of NAMPT (nicotinamide phosphoribosyltransferase) in pulmonary arterial hypertension (PAH) and now examine NAMPT regulation and extracellular NAMPT’s (eNAMPT’s) role in PAH vascular remodeling. NAMPT transcription and protein expression in human lung endothelia...

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Dades bibliogràfiques
Publicat a:Am J Respir Cell Mol Biol
Autors principals: Sun, Xiaoguang, Sun, Belinda L., Babicheva, Aleksandra, Vanderpool, Rebecca, Oita, Radu C., Casanova, Nancy, Tang, Haiyang, Gupta, Akash, Lynn, Heather, Gupta, Geetanjali, Rischard, Franz, Sammani, Saad, Kempf, Carrie L., Moreno-Vinasco, Liliana, Ahmed, Mohamed, Camp, Sara M., Wang, Jian, Desai, Ankit A., Yuan, Jason X.-J., Garcia, Joe G. N.
Format: Artigo
Idioma:Inglês
Publicat: American Thoracic Society 2020
Matèries:
Original Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7328254/
https://ncbi.nlm.nih.gov/pubmed/32142369
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2019-0164OC
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