Endothelial eNAMPT amplifies pre-clinical acute lung injury: efficacy of an eNAMPT-neutralising monoclonal antibody

RATIONALE: The severe acute respiratory syndrome coronavirus 2/coronavirus disease 2019 pandemic has highlighted the serious unmet need for effective therapies that reduce acute respiratory distress syndrome (ARDS) mortality. We explored whether extracellular nicotinamide phosphoribosyltransferase (...

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Vydáno v:Eur Respir J
Hlavní autoři: Quijada, Hector, Bermudez, Tadeo, Kempf, Carrie L., Valera, Daniel G., Garcia, Alexander N., Camp, Sara M., Song, Jin H., Franco, Evelyn, Burt, Jessica K., Sun, Belinda, Mascarenhas, Joseph B., Burns, Kimberlie, Gaber, Amir, Oita, Radu C., Reyes Hernon, Vivian, Barber, Christy, Moreno-Vinasco, Liliana, Sun, Xiaoguang, Cress, Anne E., Martin, Diego, Liu, Zhonglin, Desai, Ankit A., Natarajan, Viswanathan, Jacobson, Jeffrey R., Dudek, Steven M., Bime, Christian, Sammani, Saad, Garcia, Joe G.N.
Médium: Artigo
Jazyk:Inglês
Vydáno: European Respiratory Society 2021
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Original Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8100338/
https://ncbi.nlm.nih.gov/pubmed/33243842
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1183/13993003.02536-2020
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