eNAMPT/TLR4 signaling drives PAH cellular phenotypic switching and lung vascular remodeling

Abstract Background The attenuation of cellular phenotypic switchingdriving PAH vascular remodeling remains an unmet therapeutic need. As eNAMPT (nicotinamide phosphoribosyltransferase)/TLR4 signaling significantly contributes to PH pathobiology, an eNAMPT-neutralizing ALT-100 mAb was utilized to re...

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Main Authors: Mohamed Ahmed, Shaira L. Kee, Nahla Zaghloul, Nancy G. Casanova, Marisela Rodriguez, Carrie L. Kempf, Sara M. Camp, Jin H. Song, Saad Sammani, Akash Gupta, Andrew J. Bryant, Aikseng Ooi, Ankit A. Desai, Ayako Makino, Jason X.-J. Yuan, Panayiotis V. Benos, Zhiyu Dai, Joe G. N. Garcia
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2025-10-01
Colecção:Cell Communication and Signaling
Assuntos:
ENAMPT
DAMP
EMT
EndMT
PAH
MCT
Acesso em linha:https://doi.org/10.1186/s12964-025-02421-7
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