Direct Extracellular NAMPT Involvement in Pulmonary Hypertension and Vascular Remodeling. Transcriptional Regulation by SOX and HIF-2α

We previously demonstrated involvement of NAMPT (nicotinamide phosphoribosyltransferase) in pulmonary arterial hypertension (PAH) and now examine NAMPT regulation and extracellular NAMPT’s (eNAMPT’s) role in PAH vascular remodeling. NAMPT transcription and protein expression in human lung endothelia...

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Bibliografiske detaljer
Udgivet i:Am J Respir Cell Mol Biol
Main Authors: Sun, Xiaoguang, Sun, Belinda L., Babicheva, Aleksandra, Vanderpool, Rebecca, Oita, Radu C., Casanova, Nancy, Tang, Haiyang, Gupta, Akash, Lynn, Heather, Gupta, Geetanjali, Rischard, Franz, Sammani, Saad, Kempf, Carrie L., Moreno-Vinasco, Liliana, Ahmed, Mohamed, Camp, Sara M., Wang, Jian, Desai, Ankit A., Yuan, Jason X.-J., Garcia, Joe G. N.
Format: Artigo
Sprog:Inglês
Udgivet: American Thoracic Society 2020
Fag:
Original Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7328254/
https://ncbi.nlm.nih.gov/pubmed/32142369
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2019-0164OC
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