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In vitro-in vivo extrapolation and hepatic clearance dependent underprediction

Accurately predicting the hepatic clearance of compounds using in vitro to in vivo extrapolation (IVIVE) is crucial within the pharmaceutical industry. However several groups have recently highlighted the large error in the process. While empirical or regression-based scaling factors may be used to...

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Udgivet i:J Pharm Sci
Main Authors: Bowman, Christine M., Benet, Leslie Z.
Format: Artigo
Sprog:Inglês
Udgivet: 2019
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7325626/
https://ncbi.nlm.nih.gov/pubmed/30817922
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.xphs.2019.02.009
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