Lataa...

In Vitro–In Vivo Inaccuracy: The CYP3A4 Anomaly

When predicting hepatic clearance using in vitro to in vivo extrapolation (IVIVE), microsomes or hepatocytes are commonly used. Here, we examine intrinsic clearance values and IVIVE results in human hepatocytes and microsomes for compounds metabolized by a variety of enzymes. The great majority of C...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Drug Metab Dispos
Päätekijät: Bowman, Christine M., Benet, Leslie Z.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: The American Society for Pharmacology and Experimental Therapeutics 2019
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC7042718/
https://ncbi.nlm.nih.gov/pubmed/31551322
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.119.088427
Tagit: Lisää tagi
Ei tageja, Lisää ensimmäinen tagi!