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In Vitro–In Vivo Inaccuracy: The CYP3A4 Anomaly
When predicting hepatic clearance using in vitro to in vivo extrapolation (IVIVE), microsomes or hepatocytes are commonly used. Here, we examine intrinsic clearance values and IVIVE results in human hepatocytes and microsomes for compounds metabolized by a variety of enzymes. The great majority of C...
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| Publicado no: | Drug Metab Dispos |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The American Society for Pharmacology and Experimental Therapeutics
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7042718/ https://ncbi.nlm.nih.gov/pubmed/31551322 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.119.088427 |
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