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In vitro-in vivo extrapolation and hepatic clearance dependent underprediction
Accurately predicting the hepatic clearance of compounds using in vitro to in vivo extrapolation (IVIVE) is crucial within the pharmaceutical industry. However several groups have recently highlighted the large error in the process. While empirical or regression-based scaling factors may be used to...
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| Publicado no: | J Pharm Sci |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7325626/ https://ncbi.nlm.nih.gov/pubmed/30817922 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.xphs.2019.02.009 |
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