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Investigating the Theoretical Basis for In Vitro-In Vivo Extrapolation (IVIVE) in Predicting Drug Metabolic Clearance and Proposing Future Experimental Pathways

INTRODUCTION: Extensive studies have been conducted to predict in vivo metabolic clearance from in vitro human liver metabolism parameters (i.e., in vitro-in vivo-extrapolation; IVIVE) with little success. METHODS: Here, deriving IVIVE from first principles, we show that the product of fraction unbo...

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Bibliografiset tiedot
Julkaisussa:AAPS J
Päätekijät: Benet, Leslie Z., Sodhi, Jasleen K.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2020
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC7515557/
https://ncbi.nlm.nih.gov/pubmed/32914238
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12248-020-00501-9
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