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A Simple Methodology to Differentiate Changes in Bioavailability from Changes in Clearance Following Oral Dosing of Metabolized Drugs

Accurately discriminating changes in clearance (CL) from changes in bioavailability (F) following an oral drug-drug interaction is difficult without carrying out an IV interaction study. This may be true for drugs that are clinically-significant transporter substrates, however, for interactions that...

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Библиографические подробности
Опубликовано в: :Clin Pharmacol Ther
Главные авторы: Sodhi, Jasleen K., Benet, Leslie Z.
Формат: Artigo
Язык:Inglês
Опубликовано: 2020
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7478330/
https://ncbi.nlm.nih.gov/pubmed/32150643
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cpt.1828
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