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A Simple Methodology to Differentiate Changes in Bioavailability from Changes in Clearance Following Oral Dosing of Metabolized Drugs
Accurately discriminating changes in clearance (CL) from changes in bioavailability (F) following an oral drug-drug interaction is difficult without carrying out an IV interaction study. This may be true for drugs that are clinically-significant transporter substrates, however, for interactions that...
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| Опубликовано в: : | Clin Pharmacol Ther |
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| Главные авторы: | , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2020
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7478330/ https://ncbi.nlm.nih.gov/pubmed/32150643 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cpt.1828 |
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