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The Extended Clearance Concept Following Oral and Intravenous Dosing: Theory and Critical Analyses

PURPOSE: To derive the theoretical basis for the extended clearance model of organ elimination following both oral and IV dosing, and critically analyze the approaches previously taken. METHODS: We derived from first principles the theoretical basis for the extended clearance concept of organ elimin...

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Bibliografski detalji
Izdano u:Pharm Res
Glavni autori: Benet, Leslie Z., Bowman, Christine M., Liu, Shufang, Sodhi, Jasleen K.
Format: Artigo
Jezik:Inglês
Izdano: 2018
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6364828/
https://ncbi.nlm.nih.gov/pubmed/30349948
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11095-018-2524-0
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