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An Examination of Protein Binding and Protein-Facilitated Uptake Relating to In Vitro-In Vivo Extrapolation
As explained by the free drug theory, the unbound fraction of drug has long been thought to drive the efficacy of a molecule. Thus, the fraction unbound term, or f(u), appears in equations for fundamental pharmacokinetic parameters such as clearance, and is used when attempting in vitro to in vivo e...
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| Vydáno v: | Eur J Pharm Sci |
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| Hlavní autoři: | , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2018
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6365006/ https://ncbi.nlm.nih.gov/pubmed/30098391 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejps.2018.08.008 |
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