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An Examination of Protein Binding and Protein-Facilitated Uptake Relating to In Vitro-In Vivo Extrapolation

As explained by the free drug theory, the unbound fraction of drug has long been thought to drive the efficacy of a molecule. Thus, the fraction unbound term, or f(u), appears in equations for fundamental pharmacokinetic parameters such as clearance, and is used when attempting in vitro to in vivo e...

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Pubblicato in:Eur J Pharm Sci
Autori principali: Bowman, C.M., Benet, L.Z.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6365006/
https://ncbi.nlm.nih.gov/pubmed/30098391
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejps.2018.08.008
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