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Bufalin inhibits CYP3A4 activity in vitro and in vivo
AIM: To investigate the inhibitory interactions of bufalin and CYP3A4. METHODS: Recombinant human CYP3A4 was incubated with bufalin in vitro. Bufalin was administered ig and iv to Wistar rats to further estimate its impact on CYP3A4, and midazolam was given to index the activity of CYP3A4. RESULTS:...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4002827/ https://ncbi.nlm.nih.gov/pubmed/19417737 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2009.42 |
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