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Synoviocyte-targeted therapy synergizes with TNF inhibition in arthritis reversal

Fibroblast-like synoviocytes (FLS) are joint-lining cells that promote rheumatoid arthritis (RA) pathology. Current disease-modifying antirheumatic agents (DMARDs) operate through systemic immunosuppression. FLS-targeted approaches could potentially be combined with DMARDs to improve control of RA w...

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Pubblicato in:Sci Adv
Autori principali: Svensson, Mattias N. D., Zoccheddu, Martina, Yang, Shen, Nygaard, Gyrid, Secchi, Christian, Doody, Karen M., Slowikowski, Kamil, Mizoguchi, Fumitaka, Humby, Frances, Hands, Rebecca, Santelli, Eugenio, Sacchetti, Cristiano, Wakabayashi, Kuninobu, Wu, Dennis J., Barback, Christopher, Ai, Rizi, Wang, Wei, Sims, Gary P., Mydel, Piotr, Kasama, Tsuyoshi, Boyle, David L., Galimi, Francesco, Vera, David, Tremblay, Michel L., Raychaudhuri, Soumya, Brenner, Michael B., Firestein, Gary S., Pitzalis, Costantino, Ekwall, Anna-Karin H., Stanford, Stephanie M., Bottini, Nunzio
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Association for the Advancement of Science 2020
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Research Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7319753/
https://ncbi.nlm.nih.gov/pubmed/32637608
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aba4353
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