Synoviocyte-targeted therapy synergizes with TNF inhibition in arthritis reversal

Fibroblast-like synoviocytes (FLS) are joint-lining cells that promote rheumatoid arthritis (RA) pathology. Current disease-modifying antirheumatic agents (DMARDs) operate through systemic immunosuppression. FLS-targeted approaches could potentially be combined with DMARDs to improve control of RA w...

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Detalhes bibliográficos
Publicado no:Sci Adv
Main Authors: Svensson, Mattias N. D., Zoccheddu, Martina, Yang, Shen, Nygaard, Gyrid, Secchi, Christian, Doody, Karen M., Slowikowski, Kamil, Mizoguchi, Fumitaka, Humby, Frances, Hands, Rebecca, Santelli, Eugenio, Sacchetti, Cristiano, Wakabayashi, Kuninobu, Wu, Dennis J., Barback, Christopher, Ai, Rizi, Wang, Wei, Sims, Gary P., Mydel, Piotr, Kasama, Tsuyoshi, Boyle, David L., Galimi, Francesco, Vera, David, Tremblay, Michel L., Raychaudhuri, Soumya, Brenner, Michael B., Firestein, Gary S., Pitzalis, Costantino, Ekwall, Anna-Karin H., Stanford, Stephanie M., Bottini, Nunzio
Formato: Artigo
Idioma:Inglês
Publicado em: American Association for the Advancement of Science 2020
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7319753/
https://ncbi.nlm.nih.gov/pubmed/32637608
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aba4353
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