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DNA double strand break repair pathway choice in somatic mammalian cells

The major pathways of DNA double strand break (DSB) repair have key roles in suppressing genomic instability. However, if deployed in an inappropriate cellular context, these same repair functions can mediate chromosome rearrangements that underlie various human diseases, ranging from developmental...

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Bibliografiske detaljer
Udgivet i:Nat Rev Mol Cell Biol
Main Authors: Scully, Ralph, Panday, Arvind, Elango, Rajula, Willis, Nicholas A.
Format: Artigo
Sprog:Inglês
Udgivet: 2019
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7315405/
https://ncbi.nlm.nih.gov/pubmed/31263220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41580-019-0152-0
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