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DNA double strand break repair pathway choice in somatic mammalian cells

The major pathways of DNA double strand break (DSB) repair have key roles in suppressing genomic instability. However, if deployed in an inappropriate cellular context, these same repair functions can mediate chromosome rearrangements that underlie various human diseases, ranging from developmental...

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Détails bibliographiques
Publié dans:Nat Rev Mol Cell Biol
Auteurs principaux: Scully, Ralph, Panday, Arvind, Elango, Rajula, Willis, Nicholas A.
Format: Artigo
Langue:Inglês
Publié: 2019
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7315405/
https://ncbi.nlm.nih.gov/pubmed/31263220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41580-019-0152-0
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