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Repair Pathway Choices and Consequences at the Double-Strand Break

DNA double-strand breaks (DSBs) are cytotoxic lesions that threaten genomic integrity. Failure to repair a DSB has deleterious consequences, including genomic instability and cell death. Indeed, misrepair of DSBs can lead to inappropriate end-joining events, which commonly underlie oncogenic transfo...

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Bibliographic Details
Published in:Trends Cell Biol
Main Authors: Ceccaldi, Raphael, Rondinelli, Beatrice, D’Andrea, Alan D.
Format: Artigo
Language:Inglês
Published: 2015
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4862604/
https://ncbi.nlm.nih.gov/pubmed/26437586
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tcb.2015.07.009
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