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Repair Pathway Choices and Consequences at the Double-Strand Break
DNA double-strand breaks (DSBs) are cytotoxic lesions that threaten genomic integrity. Failure to repair a DSB has deleterious consequences, including genomic instability and cell death. Indeed, misrepair of DSBs can lead to inappropriate end-joining events, which commonly underlie oncogenic transfo...
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| Опубликовано в: : | Trends Cell Biol |
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| Главные авторы: | , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2015
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4862604/ https://ncbi.nlm.nih.gov/pubmed/26437586 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tcb.2015.07.009 |
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