Improved efficacy, tolerance, safety, and abuse liability profile of the combination of CR4056 and morphine over morphine alone in rodent models

BACKGROUND AND PURPOSE: Prolonged use of opioids causes analgesic tolerance and adverse effects including constipation and dependence. Compounds targeting imidazoline I(2) receptors are known to potentiate opioid analgesia in rodents. We investigated whether combination with the I(2) receptor ligand...

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Kaydedildi:
Detaylı Bibliyografya
Yayımlandı:Br J Pharmacol
Asıl Yazarlar: Sala, Emanuele, Ferrari, Flora, Lanza, Marco, Milia, Chiara, Sabatini, Chiara, Bonazzi, Albino, Comi, Eleonora, Borsi Franchini, Miriam, Caselli, Gianfranco, Rovati, Lucio Claudio
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: John Wiley and Sons Inc. 2020
Konular:
Research Papers
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7312436/
https://ncbi.nlm.nih.gov/pubmed/32154915
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.15049
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