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Efficacy of CR4056, a first-in-class imidazoline-2 analgesic drug, in comparison with naproxen in two rat models of osteoarthritis

PURPOSE: CR4056, (2-phenyl-6-(1H-imidazol-1yl) quinazoline), an imidazoline-2 (I2) receptor ligand, is a promising analgesic drug that has been reported to be effective in several animal models of pain. The aim of this study was to evaluate the effects of CR4056 in two well-established rat models of...

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Detalhes bibliográficos
Publicado no:J Pain Res
Main Authors: Comi, Eleonora, Lanza, Marco, Ferrari, Flora, Mauri, Valeria, Caselli, Gianfranco, Rovati, Lucio Claudio
Formato: Artigo
Idioma:Inglês
Publicado em: Dove Medical Press 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5422496/
https://ncbi.nlm.nih.gov/pubmed/28496359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/JPR.S132026
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