CR4056, a powerful analgesic imidazoline‐2 receptor ligand, inhibits the inflammation‐induced PKCε phosphorylation and membrane translocation in sensory neurons

BACKGROUND AND PURPOSE: CR4056 is a first‐in‐class imidazoline‐2 (I(2)) receptor ligand characterized by potent analgesic activity in different experimental animal models of pain. In a recent phase II clinical trial, CR4056 effectively reduced pain in patients with knee osteoarthritis. In the presen...

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Publicado en:Br J Pharmacol
Autores principales: Vellani, Vittorio, Sabatini, Chiara, Milia, Chiara, Caselli, Gianfranco, Lanza, Marco, Letari, Ornella, Rovati, Lucio Claudio, Giacomoni, Chiara
Formato: Artigo
Lenguaje:Inglês
Publicado: John Wiley and Sons Inc. 2019
Materias:
Research Papers
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6976787/
https://ncbi.nlm.nih.gov/pubmed/31454418
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14845
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