Improved efficacy, tolerance, safety, and abuse liability profile of the combination of CR4056 and morphine over morphine alone in rodent models

BACKGROUND AND PURPOSE: Prolonged use of opioids causes analgesic tolerance and adverse effects including constipation and dependence. Compounds targeting imidazoline I(2) receptors are known to potentiate opioid analgesia in rodents. We investigated whether combination with the I(2) receptor ligand...

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Detalhes bibliográficos
Publicado no:Br J Pharmacol
Main Authors: Sala, Emanuele, Ferrari, Flora, Lanza, Marco, Milia, Chiara, Sabatini, Chiara, Bonazzi, Albino, Comi, Eleonora, Borsi Franchini, Miriam, Caselli, Gianfranco, Rovati, Lucio Claudio
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7312436/
https://ncbi.nlm.nih.gov/pubmed/32154915
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.15049
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