Improved efficacy, tolerance, safety, and abuse liability profile of the combination of CR4056 and morphine over morphine alone in rodent models

BACKGROUND AND PURPOSE: Prolonged use of opioids causes analgesic tolerance and adverse effects including constipation and dependence. Compounds targeting imidazoline I(2) receptors are known to potentiate opioid analgesia in rodents. We investigated whether combination with the I(2) receptor ligand...

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Vydáno v:Br J Pharmacol
Hlavní autoři: Sala, Emanuele, Ferrari, Flora, Lanza, Marco, Milia, Chiara, Sabatini, Chiara, Bonazzi, Albino, Comi, Eleonora, Borsi Franchini, Miriam, Caselli, Gianfranco, Rovati, Lucio Claudio
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2020
Témata:
Research Papers
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7312436/
https://ncbi.nlm.nih.gov/pubmed/32154915
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.15049
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