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Modulation of imidazoline I(2) binding sites by CR4056 relieves postoperative hyperalgesia in male and female rats
BACKGROUND AND PURPOSE: CR4056 is a novel imidazoline-2 (I(2)) ligand exhibiting potent analgesic activity in animal models of pain. In this study, we investigated the effects of CR4056 in a well-established model of postoperative pain where rats develop hyperalgesia in the injured hind paw. EXPERIM...
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| Autori principali: | , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Blackwell Publishing Ltd
2014
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4128066/ https://ncbi.nlm.nih.gov/pubmed/24758515 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12728 |
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