Efficacy of CR3294, a new benzamidine derivative, in the prevention of 5-fluorouracil-induced gastrointestinal mucositis and diarrhea in mice

PURPOSE: Gastrointestinal mucositis, commonly associated with diarrhea, is a dose-limiting toxicity of chemotherapy. The new benzamidine derivative CR3294 reduces tissue damage in animal models of intestinal inflammation. Thus, we tested whether CR3294 had the potential to prevent chemotherapy-induc...

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Bibliographic Details
Main Authors: Letari, Ornella, Booth, Catherine, Bonazzi, Albino, Garofalo, Paolo, Makovec, Francesco, Rovati, Lucio C., Caselli, Gianfranco
Format: Artigo
Language:Inglês
Published: Springer-Verlag 2009
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Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2926937/
https://ncbi.nlm.nih.gov/pubmed/20041326
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-009-1224-1
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