Aberrant subchondral osteoblastic metabolism modifies Na(V)1.8 for osteoarthritis

Pain is the most prominent symptom of osteoarthritis (OA) progression. However, the relationship between pain and OA progression remains largely unknown. Here we report osteoblast secret prostaglandin E2 (PGE2) during aberrant subchondral bone remodeling induces pain and OA progression in mice. Spec...

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Bibliografiske detaljer
Udgivet i:eLife
Main Authors: Zhu, Jianxi, Zhen, Gehua, An, Senbo, Wang, Xiao, Wan, Mei, Li, Yusheng, Chen, Zhiyong, Guan, Yun, Dong, Xinzhong, Hu, Yihe, Cao, Xu
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications, Ltd 2020
Fag:
Human Biology and Medicine
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7308086/
https://ncbi.nlm.nih.gov/pubmed/32441256
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.57656
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