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Aberrant subchondral osteoblastic metabolism modifies Na(V)1.8 for osteoarthritis
Pain is the most prominent symptom of osteoarthritis (OA) progression. However, the relationship between pain and OA progression remains largely unknown. Here we report osteoblast secret prostaglandin E2 (PGE2) during aberrant subchondral bone remodeling induces pain and OA progression in mice. Spec...
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| Izdano u: | eLife |
|---|---|
| Glavni autori: | , , , , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
eLife Sciences Publications, Ltd
2020
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7308086/ https://ncbi.nlm.nih.gov/pubmed/32441256 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.57656 |
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