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Aberrant subchondral osteoblastic metabolism modifies Na(V)1.8 for osteoarthritis
Pain is the most prominent symptom of osteoarthritis (OA) progression. However, the relationship between pain and OA progression remains largely unknown. Here we report osteoblast secret prostaglandin E2 (PGE2) during aberrant subchondral bone remodeling induces pain and OA progression in mice. Spec...
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| Pubblicato in: | eLife |
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| Autori principali: | , , , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
eLife Sciences Publications, Ltd
2020
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7308086/ https://ncbi.nlm.nih.gov/pubmed/32441256 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.57656 |
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