Aberrant subchondral osteoblastic metabolism modifies Na(V)1.8 for osteoarthritis

Pain is the most prominent symptom of osteoarthritis (OA) progression. However, the relationship between pain and OA progression remains largely unknown. Here we report osteoblast secret prostaglandin E2 (PGE2) during aberrant subchondral bone remodeling induces pain and OA progression in mice. Spec...

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Dades bibliogràfiques
Publicat a:eLife
Autors principals: Zhu, Jianxi, Zhen, Gehua, An, Senbo, Wang, Xiao, Wan, Mei, Li, Yusheng, Chen, Zhiyong, Guan, Yun, Dong, Xinzhong, Hu, Yihe, Cao, Xu
Format: Artigo
Idioma:Inglês
Publicat: eLife Sciences Publications, Ltd 2020
Matèries:
Human Biology and Medicine
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7308086/
https://ncbi.nlm.nih.gov/pubmed/32441256
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.57656
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