Angiogenesis stimulated by elevated PDGF-BB in subchondral bone contributes to osteoarthritis development

Increased subchondral bone angiogenesis with blood vessels breaching the tidemark into the avascular cartilage is a diagnostic feature of human osteoarthritis. However, the mechanisms that initiate subchondral bone angiogenesis remain unclear. We show that abnormally increased platelet-derived growt...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Su, Weiping, Liu, Guanqiao, Liu, Xiaonan, Zhou, Yangying, Sun, Qi, Zhen, Gehua, Wang, Xiao, Hu, Yihe, Gao, Peisong, Demehri, Shadpour, Cao, Xu, Wan, Mei
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7205438/
https://ncbi.nlm.nih.gov/pubmed/32208385
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.135446
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