Inhibition of cyclooxygenase-2 activity in subchondral bone modifies a subtype of osteoarthritis

Osteoarthritis (OA) causes the destruction of joints. Its pathogenesis is still under investigation, and there is no effective disease-modifying therapy. Here, we report that elevated cyclooxygenase-2 (COX-2) expression in the osteocytes of subchondral bone causes both spontaneous OA and rheumatoid...

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Pubblicato in:Bone Res
Autori principali: Tu, Manli, Yang, Mi, Yu, Nanxi, Zhen, Gehua, Wan, Mei, Liu, Wenlong, Ji, Baochao, Ma, Hairong, Guo, Qiaoyue, Tong, Peijian, Cao, Li, Luo, Xianghang, Cao, Xu
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6804921/
https://ncbi.nlm.nih.gov/pubmed/31666999
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41413-019-0071-x
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