Fluvastatin Induces Apoptosis in Primary and Transformed Mast Cells

Statin drugs are widely employed in the clinic to reduce serum cholesterol. Because of their hydroxymethylglutaryl coenzyme A reductase antagonism, statins also reduce isoprenyl lipids necessary for the membrane anchorage and signaling of small G-proteins in the Ras superfamily. We previously found...

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Bibliografske podrobnosti
izdano v:J Pharmacol Exp Ther
Main Authors: Paez, Patrick A., Kolawole, Motunrayo, Taruselli, Marcela T., Ajith, Siddarth, Dailey, Jordan M., Kee, Sydney A., Haque, Tamara T., Barnstein, Brian O., McLeod, Jamie Josephine Avila, Caslin, Heather L., Kiwanuka, Kasalina N., Fukuoka, Yoshihiro, Le, Quang T., Schwartz, Lawrence B., Straus, David B., Gewirtz, David A., Martin, Rebecca K., Ryan, John J.
Format: Artigo
Jezik:Inglês
Izdano: The American Society for Pharmacology and Experimental Therapeutics 2020
Teme:
Inflammation, Immunopharmacology, and Asthma
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7306917/
https://ncbi.nlm.nih.gov/pubmed/32434944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.119.264234
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