Fluvastatin Induces Apoptosis in Primary and Transformed Mast Cells

Statin drugs are widely employed in the clinic to reduce serum cholesterol. Because of their hydroxymethylglutaryl coenzyme A reductase antagonism, statins also reduce isoprenyl lipids necessary for the membrane anchorage and signaling of small G-proteins in the Ras superfamily. We previously found...

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Bibliografiske detaljer
Udgivet i:J Pharmacol Exp Ther
Main Authors: Paez, Patrick A., Kolawole, Motunrayo, Taruselli, Marcela T., Ajith, Siddarth, Dailey, Jordan M., Kee, Sydney A., Haque, Tamara T., Barnstein, Brian O., McLeod, Jamie Josephine Avila, Caslin, Heather L., Kiwanuka, Kasalina N., Fukuoka, Yoshihiro, Le, Quang T., Schwartz, Lawrence B., Straus, David B., Gewirtz, David A., Martin, Rebecca K., Ryan, John J.
Format: Artigo
Sprog:Inglês
Udgivet: The American Society for Pharmacology and Experimental Therapeutics 2020
Fag:
Inflammation, Immunopharmacology, and Asthma
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7306917/
https://ncbi.nlm.nih.gov/pubmed/32434944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.119.264234
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