Didox (3,4-dihydroxybenzohydroxamic acid) suppresses IgE-mediated mast cell activation through attenuation of NFκB and AP-1 transcription

Mast cell activation via the high-affinity IgE receptor (FcεRI) elicits production of inflammatory mediators central to allergic disease. As a synthetic antioxidant and a potent ribonucleotide reductase (RNR) inhibitor, Didox (3,4-dihyroxybenzohydroxamic acid) has been tested in clinical trials for...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Cell Immunol
Main Authors: McLeod, Jamie Josephine Avila, Caslin, Heather L., Spence, Andrew J., Kolawole, Elizabeth M., Abdul Qayum, Amina, Paranjape, Anuya, Taruselli, Marcela, Haque, Tamara T., Kiwanuka, Kasalina N., Elford, Howard L., Ryan, John J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5733711/
https://ncbi.nlm.nih.gov/pubmed/28964543
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cellimm.2017.09.008
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados