Didox (3,4-dihydroxybenzohydroxamic acid) suppresses IgE-mediated mast cell activation through attenuation of NFκB and AP-1 transcription

Mast cell activation via the high-affinity IgE receptor (FcεRI) elicits production of inflammatory mediators central to allergic disease. As a synthetic antioxidant and a potent ribonucleotide reductase (RNR) inhibitor, Didox (3,4-dihyroxybenzohydroxamic acid) has been tested in clinical trials for...

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Bibliografske podrobnosti
izdano v:Cell Immunol
Main Authors: McLeod, Jamie Josephine Avila, Caslin, Heather L., Spence, Andrew J., Kolawole, Elizabeth M., Abdul Qayum, Amina, Paranjape, Anuya, Taruselli, Marcela, Haque, Tamara T., Kiwanuka, Kasalina N., Elford, Howard L., Ryan, John J.
Format: Artigo
Jezik:Inglês
Izdano: 2017
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5733711/
https://ncbi.nlm.nih.gov/pubmed/28964543
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cellimm.2017.09.008
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