Multivalent assembly of KRAS with the RAS-binding and cysteine-rich domains of CRAF on the membrane

Membrane anchoring of farnesylated KRAS is critical for activation of RAF kinases, yet our understanding of how these proteins interact on the membrane is limited to isolated domains. The RAS-binding domain (RBD) and cysteine-rich domain (CRD) of RAF engage KRAS and the plasma membrane, unleashing t...

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Dettagli Bibliografici
Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Fang, Zhenhao, Lee, Ki-Young, Huo, Ku-Geng, Gasmi-Seabrook, Geneviève, Zheng, Le, Moghal, Nadeem, Tsao, Ming-Sound, Ikura, Mitsuhiko, Marshall, Christopher B.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2020
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7275734/
https://ncbi.nlm.nih.gov/pubmed/32414921
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1914076117
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