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Multivalent assembly of KRAS with the RAS-binding and cysteine-rich domains of CRAF on the membrane
Membrane anchoring of farnesylated KRAS is critical for activation of RAF kinases, yet our understanding of how these proteins interact on the membrane is limited to isolated domains. The RAS-binding domain (RBD) and cysteine-rich domain (CRD) of RAF engage KRAS and the plasma membrane, unleashing t...
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| 出版年: | Proc Natl Acad Sci U S A |
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| 主要な著者: | , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
National Academy of Sciences
2020
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7275734/ https://ncbi.nlm.nih.gov/pubmed/32414921 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1914076117 |
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